Endocrine Abstracts

Binge-eating disorder is the most prevalent eating disorder diagnosed, affecting three times more women than men. It is characterised by binge-eating episodes: the rapid consumption of a large amount of food, without needing the calories. The gut hormone ghrelin stimulates appetite and reward signalling, and loss of its receptor reduces binge-eating behaviour in male mice. We aimed to examine the influence of ghrelin itself on binge-eating behaviour in mice of both sexes. 5-we...

Introduction: Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in regions of the hypothalamus regulating appetite and energy expenditure. Extensive evidence from genetic and biological studies show that MC4R is a key player in the homeostatic regulation of body weight. MC4R loss of function (LoF) variants are the most common cause of monogenic obesity. We have identified 13 heterozygous MC4R variants in patients with obesity at our academic Obesity Cent...